My research concerns the contribution of genetic factors to complex traits and the use of genetic data within frameworks of epidemiological analysis allowing causal inference. My early work on Mendelian randomization represented an important development in applied epidemiology. Following this, work at the Wellcome Trust Centre for Human Genetics at Oxford University (including work on type 2 diabetes and the fat mass and obesity related locus “FTO”) allowed me to develop in the field of genetic epidemiology. I have since been a part of the teams initiating the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia (which have publications in Nature Genetics) and have been responsible for the participation of the Avon Longitudinal Study of Parents and Children (ALSPAC) in other major international consortia.
I have also conceived of and established a new cohort (Anthropometry and Pigmentation in The Solomon Islands with findings published in Science 2012) the UK10K population based whole genome sequencing initiative. I am currently a programme track lead within the MRC Integrative Epidemiology Unit (IEU) at the University of Bristol and co-lead a work package within the CRUK funded Integrative Cancer Epidemiology Programme based around recall by genotype studies.
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